Does berberine have anti mold activity? - Body of Harmony

Does berberine have anti mold activity?

by: Payam Hakimi
April 2025
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Yes, berberine has anti-mold activity.

Berberine, a natural isoquinoline alkaloid, has demonstrated broad-spectrum anti-fungal activity, including against mold species. Studies have shown that berberine exhibits significant anti-fungal effects through multiple mechanisms, such as disrupting cell wall and membrane integrity, inhibiting ergosterol biosynthesis, and generating oxidative stress in fungal cells.[1-12]

For example, berberine has been shown to inhibit the growth of various fungal species, including Candida albicans, Cryptococcus neoformans, and Trichophyton species, which are known to cause mold infections.[1-3] The anti-fungal activity of berberine is attributed to its ability to inhibit.

it key fungal enzymes like CYP51, which is involved in ergosterol biosynthesis, a critical component of fungal cell membranes.[1]

Additionally, berberine has been found to be effective against fluconazole-resistant strains of fungi, further highlighting its potential as a therapeutic agent in treating fungal infections, including those caused by mold.[2][6][8]