Scientific Evidence of Glycerophosphocholine (GPC) - Body of Harmony

Scientific Evidence of Glycerophosphocholine (GPC)

by: Payam Hakimi
March 2025
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Glycerophosphocholine (GPC), commonly known as Alpha-GPC, is a choline-containing compound that plays a vital role in brain health, cognitive function, and physical performance. It is a precursor to acetylcholine, an essential neurotransmitter involved in memory, learning, and muscle control. Scientific research has explored its benefits in neuroprotection, cognitive enhancement, sports performance, and overall brain function.

1. Cognitive Enhancement & Neuroprotection

How It Helps: Alpha-GPC increases acetylcholine levels in the brain, which is essential for memory, learning, and cognitive processing.
Scientific Evidence: A study published in Journal of International Medical Research (1992) found that Alpha-GPC improved cognitive function in patients with mild to moderate Alzheimer’s disease.
Study: Gatti et al., Journal of International Medical Research, 1992.
Additional Research: A meta-analysis in Clinical Therapeutics (2003) found that Alpha-GPC supplementation significantly improved cognitive symptoms in patients with dementia and stroke.
Study: Parnetti et al., Clinical Therapeutics, 2003.

2. Stroke Recovery & Brain Injury Support

How It Helps: Alpha-GPC has been shown to support brain recovery after ischemic stroke by enhancing neuroplasticity and improving cholinergic neurotransmission.
Scientific Evidence: A clinical trial in Annals of the New York Academy of Sciences (1994) showed that post-stroke patients receiving Alpha-GPC had better cognitive and functional recovery than those without supplementation.
Study: Barbagallo et al., Annals of the New York Academy of Sciences, 1994.

3. Sports Performance & Growth Hormone Stimulation

How It Helps: Alpha-GPC has been shown to increase growth hormone secretion, enhance muscle power, and improve endurance.
Scientific Evidence: A study in Journal of the International Society of Sports Nutrition (2008) found that Alpha-GPC supplementation led to a significant increase in growth hormone levels and improved lower-body power output in athletes.
Study: Ziegenfuss et al., Journal of the International Society of Sports Nutrition, 2008.

4. Mood & Neurological Health

How It Helps: Alpha-GPC helps regulate neurotransmitter balance, supporting mood stability and mental well-being.
Scientific Evidence: A study in Clinical Neuropharmacology (1993) showed that Alpha-GPC supplementation improved mood and cognitive function in individuals with mood disorders.
Study: Fioravanti et al., Clinical Neuropharmacology, 1993.

5. Potential Benefits for Age-Related Cognitive Decline

How It Helps: Alpha-GPC protects against age-related decline by maintaining acetylcholine levels and promoting neuronal integrity.
Scientific Evidence: A long-term study in Dementia and Geriatric Cognitive Disorders (2001) found that Alpha-GPC delayed cognitive deterioration in elderly patients with memory decline.
Study: Parnetti et al., Dementia and Geriatric Cognitive Disorders, 2001.

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